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Title:

Anti-inflammatory chemoprevention attenuates the phenotype in a mouse model of esophageal adenocarcinoma.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural
Author(s):
Baumeister, Theresa; Ingermann, Jonas; Marcazzan, Sabrina; Fang, Hsin-Yu; Oellinger, Rupert; Rad, Roland; Engleitner, Thomas; Kleigrewe, Karin; Anand, Akanksha; Strangmann, Julia; Schmid, Roland M; Wang, Timothy C; Quante, Michael
Abstract:
Barrett's esophagus (BE) is the main known precursor condition of esophageal adenocarcinoma (EAC). BE is defined by the presence of metaplasia above the normal squamous columnar junction and has mainly been attributed to gastroesophageal reflux disease and chronic reflux esophagitis. Thus, the rising incidence of EAC in the Western world is probably mediated by chronic esophageal inflammation, secondary to gastroesophageal reflux disease in combination with environmental risk factors such as a W...     »
Journal title abbreviation:
Carcinogenesis
Year:
2021
Journal volume:
42
Journal issue:
8
Pages contribution:
1068-1078
Fulltext / DOI:
doi:10.1093/carcin/bgab032
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33878160
Print-ISSN:
0143-3334
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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