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Title:

Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hartleben, Goetz; Schorpp, Kenji; Kwon, Yun; Betz, Barbara; Tsokanos, Foivos-Filippos; Dantes, Zahra; Schäfer, Arlett; Rothenaigner, Ina; Monroy Kuhn, José Manuel; Morigny, Pauline; Mehr, Lisa; Lin, Sean; Seitz, Susanne; Tokarz, Janina; Artati, Anna; Adamsky, Jerzy; Plettenburg, Oliver; Lutter, Dominik; Irmler, Martin; Beckers, Johannes; Reichert, Maximilian; Hadian, Kamyar; Zeigerer, Anja; Herzig, Stephan; Berriel Diaz, Mauricio
Abstract:
By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi-agent therapies have emerged as key approaches in the treatment of complex diseases, most notably cancer. Using high-throughput drug screens, we uncovered distinct metabolic vulnerabilities and thereby identified drug combinations synergistically causing a starvation-like lethal catabolic response in tumor cells from different cancer entities. Domperidone, a dopamine receptor antagonist, as well as several tri...     »
Journal title abbreviation:
EMBO Mol Med
Year:
2021
Journal volume:
13
Journal issue:
4
Fulltext / DOI:
doi:10.15252/emmm.202012461
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33665961
Print-ISSN:
1757-4676
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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