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Titel:

A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wierer, Michael; Werner, Julia; Wobst, Jana; Kastrati, Adnan; Cepele, Ganildo; Aherrahrou, Redouane; Sager, Hendrik B; Erdmann, Jeanette; Dichgans, Martin; Flockerzi, Veit; Civelek, Mete; Dietrich, Alexander; Mann, Matthias; Schunkert, Heribert; Kessler, Thorsten
Abstract:
AIMS: In-stent restenosis is a complication after coronary stenting associated with morbidity and mortality. Here, we sought to investigate the molecular processes underlying neointima formation and to identify new treatment and prevention targets. METHODS AND RESULTS: Neointima formation was induced by wire injury in mouse femoral arteries. High-accuracy proteomic measurement of single femoral arteries to a depth of about 5000 proteins revealed massive proteome remodelling, with more than half...     »
Zeitschriftentitel:
Eur Heart J
Jahr:
2021
Band / Volume:
42
Heft / Issue:
18
Seitenangaben Beitrag:
1773-1785
Volltext / DOI:
doi:10.1093/eurheartj/ehab140
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33829256
Print-ISSN:
0195-668X
TUM Einrichtung:
657; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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