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Titel:

Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants.

Dokumenttyp:
Journal Article
Autor(en):
Li, Shuai; Silvestri, Valentina; Leslie, Goska; Rebbeck, Timothy R; Neuhausen, Susan L; Hopper, John L; Nielsen, Henriette Roed; Lee, Andrew; Yang, Xin; McGuffog, Lesley; Parsons, Michael T; Andrulis, Irene L; Arnold, Norbert; Belotti, Muriel; Borg, Åke; Buecher, Bruno; Buys, Saundra S; Caputo, Sandrine M; Chung, Wendy K; Colas, Chrystelle; Colonna, Sarah V; Cook, Jackie; Daly, Mary B; de la Hoya, Miguel; de Pauw, Antoine; Delhomelle, Hélène; Eason, Jacqueline; Engel, Christoph; Evans, D Gareth;...     »
Abstract:
PURPOSE: To provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management. METHODS: We used data from 3,184 BRCA1 and 2,157 BRCA2 families in the Consortium of Investigators of Modifiers of BRCA1/2 to estimate age-specific relative (RR) and absolute risks for 22 first primary cancer types adjusting for family ascertainment. RESULTS: BRCA1 PVs were associated wit...     »
Zeitschriftentitel:
J Clin Oncol
Jahr:
2022
Band / Volume:
40
Heft / Issue:
14
Seitenangaben Beitrag:
1529-1541
Volltext / DOI:
doi:10.1200/JCO.21.02112
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35077220
Print-ISSN:
0732-183X
TUM Einrichtung:
1072; 183; 597; Klinik und Poliklinik für Frauenheilkunde
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