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Titel:

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Autor(en):
Flitsch, Lea Jessica; Börner, Kathleen; Stüllein, Christian; Ziegler, Simon; Sonntag-Buck, Vera; Wiedtke, Ellen; Semkova, Vesselina; Au Yeung, Si Wah Christina; Schlee, Julia; Hajo, Mohamad; Mathews, Mona; Ludwig, Beatrice Stefanie; Kossatz, Susanne; Kessler, Horst; Grimm, Dirk; Brüstle, Oliver
Abstract:
Human brain cells generated by in vitro cell programming provide exciting prospects for disease modeling, drug discovery and cell therapy. These applications frequently require efficient and clinically compliant tools for genetic modification of the cells. Recombinant adeno-associated viruses (AAVs) fulfill these prerequisites for a number of reasons, including the availability of a myriad of AAV capsid variants with distinct cell type specificity (also called tropism). Here, we harnessed a cust...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2022
Band / Volume:
12
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41598-022-12404-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35589936
Print-ISSN:
2045-2322
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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