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- Original title:
- Design, synthesis, and structure-function studies of peptides as inhibitors of the MIF/chemokine receptor axis
- Translated title:
- Design, Synthese und Struktur-Funktions-Untersuchungen von Peptiden als Inhibitoren der MIF/Chemokinrezeptor Achse
- Author:
- Kontos, Christos
- Year:
- 2021
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Life Sciences
- Advisor:
- Kapurniotu, Aphrodite (Prof. Dr.)
- Referee:
- Kapurniotu, Aphrodite (Prof. Dr.); Langosch, Dieter (Prof. Dr.); Bartelt, Alexander (Prof. Dr.)
- Language:
- en
- Subject group:
- NAT Naturwissenschaften (allgemein)
- TUM classification:
- CHE 820
- Abstract:
- Macrophage migration-inhibitory factor (MIF) is an atypical chemokine that induces atherosclerosis through binding to the chemokine receptors CXCR2 and CXCR4. However, the CXCL12/CXCR4 and MIF/CD74 pathways also promote athero- and cardioprotection. The thesis describes the design, synthesis, and structure-function studies of peptides that were designed to block the disease-exacerbating receptor interactions of MIF and spare the protective pathways.
- Translated abstract:
- Macrophage Migration Inhibitory Factor (MIF) ist ein atypisches Chemokin, das Atherosklerose über die Chemokinrezeptoren CXCR2 und CXCR4 auslöst. Die Signalachsen CXCL12/CXCR4 und MIF/CD74 fördern jedoch auch die Athero- und Kardioprotektion. Diese Arbeit beschreibt Design, Synthese und Struktur-Funktionsbeziehungs-Untersuchungen von Peptiden, die die pathogenen Interaktionen von MIF blockieren und die schützenden Wege dagegen verschonen sollen.
- WWW:
- https://mediatum.ub.tum.de/?id=1624773
- Date of submission:
- 22.09.2021
- Oral examination:
- 30.11.2021
- File size:
- 18132438 bytes
- Pages:
- 295
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20211130-1624773-1-5
- Last change:
- 30.11.2022
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