Detection of early signs of right ventricular systolic impairment in unoperated Ebstein's anomaly by cardiac magnetic resonance feature tracking.

Baessato, Francesca; Furtmüller, Claudia; Shehu, Nerejda; Ferrari, Irene; Reich, Bettina; Nagdyman, Nicole; Martinoff, Stefan; Stern, Heiko; Ewert, Peter; Meierhofer, Christian

doi:10.21037/cdt-22-82

2022

Back
Back to start of result list
Permanent link for displayed object

Title:: Detection of early signs of right ventricular systolic impairment in unoperated Ebstein's anomaly by cardiac magnetic resonance feature tracking.
Document type:: Journal Article
Author(s):: Baessato, Francesca; Furtmüller, Claudia; Shehu, Nerejda; Ferrari, Irene; Reich, Bettina; Nagdyman, Nicole; Martinoff, Stefan; Stern, Heiko; Ewert, Peter; Meierhofer, Christian
Abstract:: BACKGROUND: Cardiovascular magnetic resonance feature-tracking analysis (CMR-FT) provides a quantitative assessment of myocardial contraction with potential for diagnostic and prognostic ability in a wide spectrum of diseases. Ebstein's anomaly (EA) is a rare congenital heart disease characterized by apical displacement of the tricuspid valve. However, it is also considered a disorder of development affecting the global right ventricular myocardium. Aim of our study is to describe the complex contractile mechanics of the functional right ventricle (RV) in patients affected by EA through CMR-FT. METHODS: Fifty surgery-free EA patients who had undergone a complete CMR protocol at our institution between January 2017 and December 2020 were selected for the retrospective study. A historical control group of twenty-five healthy subjects was also included. CMR-FT analysis was performed at a dedicated workstation by manually tracing RV endo- end epicardial borders on steady-state-free-precession (SSFP) cine images. Strain values were calculated. Apical displacement of the tricuspid valve (TV) was measured on a 4-chamber cine image from the right atrio-ventricular junction to the functional annulus of the TV. RESULTS: EA patients presented significantly impaired RV global radial strain (GRS) and global circumferential strain (GCS) compared to controls (P<0.0001 and P=0.0008, respectively). In a subgroup analysis, GRS was significantly compromised in patients with a severely displaced TV (>16 mm/m2) compared to milder forms (P=0.03) and to controls (P<0.0001). Among EA patients with a preserved ejection fraction, 12 (48%) vs. 6 (24%) controls had reduced both GRS and GCS. CONCLUSIONS: The contractile pattern of the functional RV in EA is characterised by prevalent alterations in the short-axis direction as indicated by reduced GRS and GCS. Strain values might be reduced prior to routine used functional parameters like RV ejection fraction (RVEF) and can possibly serve as an early predictor of myocardial dysfunction in EA patients.
Journal title abbreviation:: Cardiovasc Diagn Ther
Year:: 2022
Journal volume:: 12
Journal issue:: 3
Pages contribution:: 278-288
Fulltext / DOI:: doi:10.21037/cdt-22-82
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/35800351
Print-ISSN:: 2223-3652
TUM Institution:: Institut für Radiologie und Nuklearmedizin; Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Ewert)
BibTeX