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Titel:

Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Bohnacker, Sina; Hartung, Franziska; Henkel, Fiona; Quaranta, Alessandro; Kolmert, Johan; Priller, Alina; Ud-Dean, Minhaz; Giglberger, Johanna; Kugler, Luisa M; Pechtold, Lisa; Yazici, Sarah; Lechner, Antonie; Erber, Johanna; Protzer, Ulrike; Lingor, Paul; Knolle, Percy; Chaker, Adam M; Schmidt-Weber, Carsten B; Wheelock, Craig E; Esser-von Bieren, Julia
Abstract:
Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of eicosanoids in airway inflammation. Here we report that MDM from SARS-CoV-2-infected individuals with mild disease show an inflammatory transcriptional and metabolic imprint that lasts for at least 5 months after SARS-CoV-2 infection. MDM from convalescent SARS-CoV-2-infected individuals showed a downregulation of pro-resolving factors...     »
Zeitschriftentitel:
Mucosal Immunol
Jahr:
2022
Band / Volume:
15
Heft / Issue:
3
Seitenangaben Beitrag:
515-524
Volltext / DOI:
doi:10.1038/s41385-021-00482-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35288643
Print-ISSN:
1933-0219
TUM Einrichtung:
Institut für Virologie (Prof. Protzer); Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Klinik und Poliklinik für Neurologie (Prof. Hemmer); Lehrstuhl für Molekulare Allergologie und Umweltforschung (Prof. Schmidt-Weber); Roman Herzog Comprehensive Cancer Center
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