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Titel:

Inflammatory macrophage memory in nonsteroidal anti-inflammatory drug-exacerbated respiratory disease.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Haimerl, Pascal; Bernhardt, Ulrike; Schindela, Sonja; Henkel, Fiona D R; Lechner, Antonie; Zissler, Ulrich M; Pastor, Xavier; Thomas, Dominique; Cecil, Alexander; Ge, Yan; Haid, Mark; Prehn, Cornelia; Tokarz, Janina; Heinig, Matthias; Adamski, Jerzy; Schmidt-Weber, Carsten B; Chaker, Adam M; Esser-von Bieren, Julia
Abstract:
BACKGROUND: Nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is a chronic inflammatory condition, which is driven by an aberrant arachidonic acid metabolism. Macrophages are major producers of arachidonic acid metabolites and subject to metabolic reprogramming, but they have been neglected in N-ERD. OBJECTIVE: This study sought to elucidate a potential metabolic and epigenetic macrophage reprogramming in N-ERD. METHODS: Transcriptional, metabolic, and lipid mediator pr...     »
Zeitschriftentitel:
J Allergy Clin Immunol
Jahr:
2021
Band / Volume:
147
Heft / Issue:
2
Seitenangaben Beitrag:
587-599
Volltext / DOI:
doi:10.1016/j.jaci.2020.04.064
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32540397
Print-ISSN:
0091-6749
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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