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Title:

MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening.

Document type:
Article; Journal Article
Author(s):
Schellinger, Isabel N; Wagenhäuser, Markus; Chodisetti, Giriprakash; Mattern, Karin; Dannert, Angelika; Petzold, Anne; Jakubizka-Smorag, Joanna; Emrich, Fabian; Haunschild, Josephina; Schuster, Andreas; Schwob, Elisabeth; Schulz, Kei; Maegdefessel, Lars; Spin, Joshua M; Stumvoll, Michael; Hasenfuß, Gerd; Tsao, Philip S; Raaz, Uwe
Abstract:
Patients with type 2 diabetes (T2D) are threatened by excessive cardiovascular morbidity and mortality. While accelerated arterial stiffening may represent a critical mechanistic factor driving cardiovascular risk in T2D, specific therapies to contain the underlying diabetic arterial remodeling have been elusive. The present translational study investigates the role of microRNA-29b (miR-29b) as a driver and therapeutic target of diabetic aortic remodeling and stiffening. Using a murine model (db...     »
Journal title abbreviation:
Mol Ther Nucleic Acids
Year:
2021
Journal volume:
24
Pages contribution:
188-199
Fulltext / DOI:
doi:10.1016/j.omtn.2021.02.021
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33767915
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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