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Title:

Colchicine Impacts Leukocyte Trafficking in Atherosclerosis and Reduces Vascular Inflammation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Meyer-Lindemann, Ulrike; Mauersberger, Carina; Schmidt, Anna-Christina; Moggio, Aldo; Hinterdobler, Julia; Li, Xinghai; Khangholi, David; Hettwer, Jan; Gräßer, Christian; Dutsch, Alexander; Schunkert, Heribert; Kessler, Thorsten; Sager, Hendrik B
Abstract:
BACKGROUND: Inflammation strongly contributes to atherosclerosis initiation and progression. Consequently, recent clinical trials pharmacologically targeted vascular inflammation to decrease the incidence of atherosclerosis-related complications. Colchicine, a microtubule inhibitor with anti-inflammatory properties, reduced cardiovascular events in patients with recent acute coronary syndrome and chronic coronary disease. However, the biological basis of these observations remains elusive. We so...     »
Journal title abbreviation:
Front Immunol
Year:
2022
Journal volume:
13
Fulltext / DOI:
doi:10.3389/fimmu.2022.898690
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35860249
Print-ISSN:
1664-3224
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert); Klinik und Poliklinik für Innere Medizin I, Kardiologie
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