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Titel:

Disorders of histone methylation: Molecular basis and clinical syndromes.

Dokumenttyp:
Journal Article; Review
Autor(en):
Al Ojaimi, Mode; Banimortada, Bashar J; Othman, Amna; Riedhammer, Korbinian M; Almannai, Mohammed; El-Hattab, Ayman W
Abstract:
Epigenetic modifications of DNA and histone tails are essential for gene expression regulation. They play an essential role in neurodevelopment as nervous system development is a complex process requiring a dynamic pattern of gene expression. Histone methylation is one of the vital epigenetic regulators and mostly occurs on lysine residues of histones H3 and H4. Histone methylation is catalyzed by two sets of enzymes: histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs...     »
Zeitschriftentitel:
Clin Genet
Jahr:
2022
Band / Volume:
102
Heft / Issue:
3
Seitenangaben Beitrag:
169-181
Volltext / DOI:
doi:10.1111/cge.14181
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35713103
Print-ISSN:
0009-9163
TUM Einrichtung:
Professur für Nephrologie (Prof. Heemann)
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