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Titel:

Cis-epistasis at the LPA locus and risk of cardiovascular diseases.

Dokumenttyp:
Journal Article
Autor(en):
Zeng, Lingyao; Moser, Sylvain; Mirza-Schreiber, Nazanin; Lamina, Claudia; Coassin, Stefan; Nelson, Christopher P; Annilo, Tarmo; Franzén, Oscar; Kleber, Marcus E; Mack, Salome; Andlauer, Till F M; Jiang, Beibei; Stiller, Barbara; Li, Ling; Willenborg, Christina; Munz, Matthias; Kessler, Thorsten; Kastrati, Adnan; Laugwitz, Karl-Ludwig; Erdmann, Jeanette; Moebus, Susanne; NöThen, Markus M; Peters, Annette; Strauch, Konstantin; MüLler-Nurasyid, Martina; Gieger, Christian; Meitinger, Thomas; Steinh...     »
Abstract:
AIMS: Coronary artery disease (CAD) has a strong genetic predisposition. However, despite substantial discoveries made by genome-wide association studies (GWAS), a large proportion of heritability awaits identification. Non-additive genetic effects might be responsible for part of the unaccounted genetic variance. Here, we attempted a proof-of-concept study to identify non-additive genetic effects, namely epistatic interactions, associated with CAD. METHODS AND RESULTS: We tested for epistatic i...     »
Zeitschriftentitel:
Cardiovasc Res
Jahr:
2022
Band / Volume:
118
Heft / Issue:
4
Seitenangaben Beitrag:
1088-1102
Volltext / DOI:
doi:10.1093/cvr/cvab136
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33878186
Print-ISSN:
0008-6363
TUM Einrichtung:
1310; 1379; 656; 658; Institut für Humangenetik; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert); Klinik und Poliklinik für Innere Medizin I, Kardiologie
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