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Title:

Comprehensive characterization of central BCL-2 family members in aberrant eosinophils and their impact on therapeutic strategies.

Document type:
Article; Journal Article
Author(s):
Odinius, Timo O; Buschhorn, Lars; Wagner, Celina; Hauch, Richard T; Dill, Veronika; Dechant, Marta; Buck, Michele C; Shoumariyeh, Khalid; Moog, Philipp; Schwaab, Juliana; Reiter, Andreas; Brockow, Knut; Götze, Katharina; Bassermann, Florian; Höckendorf, Ulrike; Branca, Caterina; Jost, Philipp J; Jilg, Stefanie
Abstract:
PURPOSE: Hypereosinophilia represents a heterogenous group of severe medical conditions characterized by elevated numbers of eosinophil granulocytes in peripheral blood, bone marrow or tissue. Treatment options for hypereosinophilia remain limited despite recent approaches including IL-5-targeted monoclonal antibodies and tyrosine kinase inhibitors. METHODS: To understand aberrant survival patterns and options for pharmacologic intervention, we characterized BCL-2-regulated apoptosis signaling b...     »
Journal title abbreviation:
J Cancer Res Clin Oncol
Year:
2022
Journal volume:
148
Journal issue:
2
Pages contribution:
331-340
Fulltext / DOI:
doi:10.1007/s00432-021-03827-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34654952
Print-ISSN:
0171-5216
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Klinik und Poliklinik für Dermatologie und Allergologie
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