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Title:

Efficacy and Safety of Revacept, a Novel Lesion-Directed Competitive Antagonist to Platelet Glycoprotein VI, in Patients Undergoing Elective Percutaneous Coronary Intervention for Stable Ischemic Heart Disease: The Randomized, Double-blind, Placebo-Controlled ISAR-PLASTER Phase 2 Trial.

Document type:
Journal Article
Author(s):
Mayer, Katharina; Hein-Rothweiler, Ralph; Schüpke, Stefanie; Janisch, Marion; Bernlochner, Isabell; Ndrepepa, Gjin; Sibbing, Dirk; Gori, Tommaso; Borst, Oliver; Holdenrieder, Stefan; Kupka, Danny; Petzold, Tobias; Bradaric, Christian; Okrojek, Rainer; Leistner, David M; Trippel, Tobias D; Münzel, Thomas; Landmesser, Ulf; Pieske, Burkert; Zeiher, Andreas M; Gawaz, Meinrad P; Hapfelmeier, Alexander; Laugwitz, Karl-Ludwig; Schunkert, Heribert; Kastrati, Adnan; Massberg, Steffen
Abstract:
Importance: The assessment of new antithrombotic agents with a favorable safety profile is clinically relevant. Objective: To test the efficacy and safety of revacept, a novel, lesion-directed antithrombotic drug, acting as a competitive antagonist to platelet glycoprotein VI. Design, Setting, and Participants: A phase 2 randomized clinical trial; patients were enrolled from 9 centers in Germany from November 20, 2017, to February 27, 2020; follow-up ended on March 27, 2020. The study included...     »
Journal title abbreviation:
JAMA Cardiol
Year:
2021
Journal volume:
6
Journal issue:
7
Pages contribution:
753-761
Fulltext / DOI:
doi:10.1001/jamacardio.2021.0475
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33787834
Print-ISSN:
2380-6583
TUM Institution:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!); Institut für Medizinische Statistik und Epidemiologie; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert); Klinik und Poliklinik für Innere Medizin I, Kardiologie; Lehrstuhl für Allgemeinmedizin (Prof. Schneider) (keine SAP-Zuordnung!)
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