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Titel:

Hypoxia-Inducible Factor 1 Alpha-Mediated RelB/APOBEC3B Down-regulation Allows Hepatitis B Virus Persistence.

Dokumenttyp:
Article; Journal Article
Autor(en):
Riedl, Tobias; Faure-Dupuy, Suzanne; Rolland, Maude; Schuehle, Svenja; Hizir, Zohier; Calderazzo, Silvia; Zhuang, Xiaodong; Wettengel, Jochen; Lopez, Martin Alexander; Barnault, Romain; Mirakaj, Valbona; Prokosch, Sandra; Heide, Danijela; Leuchtenberger, Corinna; Schneider, Martin; Heßling, Bernd; Stottmeier, Benjamin; Wessbecher, Isabel M; Schirmacher, Peter; McKeating, Jane A; Protzer, Ulrike; Durantel, David; Lucifora, Julie; Dejardin, Emmanuel; Heikenwalder, Mathias
Abstract:
BACKGROUND AND AIMS: Therapeutic strategies against HBV focus, among others, on the activation of the immune system to enable the infected host to eliminate HBV. Hypoxia-inducible factor 1 alpha (HIF1α) stabilization has been associated with impaired immune responses. HBV pathogenesis triggers chronic hepatitis-related scaring, leading inter alia to modulation of liver oxygenation and transient immune activation, both factors playing a role in HIF1α stabilization. APPROACH AND RESULTS: We addres...     »
Zeitschriftentitel:
Hepatology
Jahr:
2021
Band / Volume:
74
Heft / Issue:
4
Seitenangaben Beitrag:
1766-1781
Volltext / DOI:
doi:10.1002/hep.31902
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33991110
Print-ISSN:
0270-9139
TUM Einrichtung:
Institut für Virologie
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