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Titel:

Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Stadler, Daniela; Kächele, Martin; Jones, Alisha N; Hess, Julia; Urban, Christian; Schneider, Jessica; Xia, Yuchen; Oswald, Andreas; Nebioglu, Firat; Bester, Romina; Lasitschka, Felix; Ringelhan, Marc; Ko, Chunkyu; Chou, Wen-Min; Geerlof, Arie; van de Klundert, Maarten A; Wettengel, Jochen M; Schirmacher, Peter; Heikenwälder, Mathias; Schreiner, Sabrina; Bartenschlager, Ralf; Pichlmair, Andreas; Sattler, Michael; Unger, Kristian; Protzer, Ulrike
Abstract:
Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available antivirals. Interferons can diminish HBV cccDNA via APOBEC3-mediated deamination. Here, we show that overexpression of APOBEC3A alone is not sufficient to reduce HBV cccDNA that requires additional treatment of cells with interferon indicating involvement of an interferon-stimulated gene (ISG) in cccDNA degradation. Transcriptome analyses...     »
Zeitschriftentitel:
EMBO Rep
Jahr:
2021
Band / Volume:
22
Heft / Issue:
6
Volltext / DOI:
doi:10.15252/embr.201949568
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33969602
Print-ISSN:
1469-221X
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Virologie
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