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Title:

HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site.

Document type:
Journal Article; Review
Author(s):
Zhang, Dake; Zhang, Ke; Protzer, Urlike; Zeng, Changqing
Abstract:
Hepatitis B virus (HBV), one of the well-known DNA oncogenic viruses, is the leading cause of hepatocellular carcinoma (HCC). In infected hepatocytes, HBV DNA can be integrated into the host genome through an insertional mutagenesis process inducing tumorigenesis. Dissection of the genomic features surrounding integration sites will deepen our understanding of mechanisms underlying integration. Moreover, the quantity and biological activity of integration sites may reflect the DNA damage within...     »
Journal title abbreviation:
J Clin Transl Hepatol
Year:
2021
Journal volume:
9
Journal issue:
3
Pages contribution:
399-408
Fulltext / DOI:
doi:10.14218/JCTH.2021.00062
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34221926
Print-ISSN:
2225-0719
TUM Institution:
Institut für Virologie
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