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Title:

Transcript-Activated Coatings on Titanium Mediate Cellular Osteogenesis for Enhanced Osteointegration.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Fayed, Omnia; van Griensven, Martijn; Tahmasebi Birgani, Zeinab; Plank, Christian; Balmayor, Elizabeth R
Abstract:
Osteointegration is one of the most important factors for implant success. Several biomolecules have been used as part of drug delivery systems to improve implant integration into the surrounding bone tissue. Chemically modified mRNA (cmRNA) is a new form of therapeutic that has been used to induce bone healing. Combined with biomaterials, cmRNA can be used to develop transcript-activated matrices for local protein production with osteoinductive potential. In this study, we aimed to utilize this...     »
Journal title abbreviation:
Mol Pharm
Year:
2021
Journal volume:
18
Journal issue:
3
Pages contribution:
1121-1137
Fulltext / DOI:
doi:10.1021/acs.molpharmaceut.0c01042
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33492959
Print-ISSN:
1543-8384
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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