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Title:

Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Deschler, Sebastian; Kager, Juliane; Erber, Johanna; Fricke, Lisa; Koyumdzhieva, Plamena; Georgieva, Alexandra; Lahmer, Tobias; Wiessner, Johannes R; Voit, Florian; Schneider, Jochen; Horstmann, Julia; Iakoubov, Roman; Treiber, Matthias; Winter, Christof; Ruland, Jürgen; Busch, Dirk H; Knolle, Percy A; Protzer, Ulrike; Spinner, Christoph D; Schmid, Roland M; Quante, Michael; Böttcher, Katrin
Abstract:
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as progression to severe disease, characterised by lung and other organ failure. The immune system is considered to play a crucial role for the pathogenesis of COVID-19, although especially the contribution of innate-like T cells remains poorly understood. Here, we analysed the phenotype and function of mucosal-associated invariant...     »
Journal title abbreviation:
Viruses
Year:
2021
Journal volume:
13
Journal issue:
2
Fulltext / DOI:
doi:10.3390/v13020241
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33546489
Print-ISSN:
1999-4915
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Experimentelle Onkologie und Therapieforschung; Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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