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Title:

Targeted Hsp70 fluorescence molecular endoscopy detects dysplasia in Barrett's esophagus.

Document type:
Zeitschriftenaufsatz
Author(s):
Fang, Hsin-Yu; Stangl, Stefan; Marcazzan, Sabrina; Carvalho, Marcos J Braz; Baumeister, Theresa; Anand, Akanksha; Strangmann, Julia; Huspenina, Julia Slotta; Wang, Timothy C; Schmid, Roland M; Feith, Marcus; Friess, Helmut; Ntziachristos, Vasilis; Multhoff, Gabriele; Gorpas, Dimitris; Quante, Michael
Abstract:
PURPOSE: The incidence of esophageal adenocarcinoma (EAC) has been increasing for decades without significant improvements in treatment. Barrett's esophagus (BE) is best established risk factor for EAC, but current surveillance with random biopsies cannot predict progression to cancer in most BE patients due to the low sensitivity and specificity of high-definition white light endoscopy. METHODS: Here, we evaluated the membrane-bound highly specific Hsp70-specific contrast agent Tumor-Penetrati...     »
Journal title:
European Journal of Nuclear Medicine and Molecular Imaging
Journal title abbreviation:
Eur J Nucl Med Mol Imaging
Year:
2022
Journal volume:
49
Journal issue:
6
Pages contribution:
2049-2063
Fulltext / DOI:
doi:10.1007/s00259-021-05582-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34882260
WWW:
https://link.springer.com/article/10.1007/s00259-021-05582-y
Print-ISSN:
1619-7070
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Chirurgie; Klinik und Poliklinik für Innere Medizin II, Gastroenterologie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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