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- Titel:
COVID-19 in cancer patients: clinical characteristics and outcome-an analysis of the LEOSS registry.
- Dokumenttyp:
- Article; Journal Article
- Autor(en):
- Rüthrich, Maria Madeleine; Giessen-Jung, C; Borgmann, S; Classen, A Y; Dolff, S; Grüner, B; Hanses, F; Isberner, N; Köhler, P; Lanznaster, J; Merle, U; Nadalin, S; Piepel, C; Schneider, J; Schons, M; Strauss, R; Tometten, L; Vehreschild, J J; von Lilienfeld-Toal, M; Beutel, G; Wille, K
- Abstract:
- INTRODUCTION: Since the early SARS-CoV-2 pandemic, cancer patients have been assumed to be at higher risk for severe COVID-19. Here, we present an analysis of cancer patients from the LEOSS (Lean European Open Survey on SARS-CoV-2 Infected Patients) registry to determine whether cancer patients are at higher risk. PATIENTS AND METHODS: We retrospectively analyzed a cohort of 435 cancer patients and 2636 non-cancer patients with confirmed SARS-CoV-2 infection, enrolled between March 16 and August 31, 2020. Data on socio-demographics, comorbidities, cancer-related features and infection course were collected. Age-, sex- and comorbidity-adjusted analysis was performed. Primary endpoint was COVID-19-related mortality. RESULTS: In total, 435 cancer patients were included in our analysis. Commonest age category was 76-85 years (36.5%), and 40.5% were female. Solid tumors were seen in 59% and lymphoma and leukemia in 17.5% and 11% of patients. Of these, 54% had an active malignancy, and 22% had recently received anti-cancer treatments. At detection of SARS-CoV-2, the majority (62.5%) presented with mild symptoms. Progression to severe COVID-19 was seen in 55% and ICU admission in 27.5%. COVID-19-related mortality rate was 22.5%. Male sex, advanced age, and active malignancy were associated with higher death rates. Comparing cancer and non-cancer patients, age distribution and comorbidity differed significantly, as did mortality (14% vs 22.5%, p value < 0.001). After adjustments for other risk factors, mortality was comparable. CONCLUSION: Comparing cancer and non-cancer patients, outcome of COVID-19 was comparable after adjusting for age, sex, and comorbidity. However, our results emphasize that cancer patients as a group are at higher risk due to advanced age and pre-existing conditions.
- Zeitschriftentitel:
- Ann Hematol
- Jahr:
- 2021
- Band / Volume:
- 100
- Heft / Issue:
- 2
- Seitenangaben Beitrag:
- 383-393
- Volltext / DOI:
- doi:10.1007/s00277-020-04328-4
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/33159569
- Print-ISSN:
- 0939-5555
- TUM Einrichtung:
- 1036; 5; 608; 679; II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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