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Document type:
Article; Journal Article
Author(s):
Kiweler, Nicole; Wünsch, Désirée; Wirth, Matthias; Mahendrarajah, Nisintha; Schneider, Günter; Stauber, Roland H; Brenner, Walburgis; Butter, Falk; Krämer, Oliver H
Title:
Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes.
Abstract:
PURPOSE: We set out to determine whether clinically tested epigenetic drugs against class I histone deacetylases (HDACs) affect hallmarks of the metastatic process. METHODS: We treated permanent and primary renal, lung, and breast cancer cells with the class I histone deacetylase inhibitors (HDACi) entinostat (MS-275) and valproic acid (VPA), the replicative stress inducer hydroxyurea (HU), the DNA-damaging agent cis-platinum (L-OHP), and the cytokine transforming growth factor-β (TGFβ). We used...     »
Journal title abbreviation:
J Cancer Res Clin Oncol
Year:
2020
Journal volume:
146
Journal issue:
2
Pages contribution:
343-356
Fulltext / DOI:
doi:10.1007/s00432-019-03118-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31932908
Print-ISSN:
0171-5216
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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