Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study.

Then, Cornelia; Thorand, Barbara; Then, Holger L; Meisinger, Christa; Heier, Margit; Peters, Annette; Koenig, Wolfgang; Rathmann, Wolfgang; Bidlingmaier, Martin; Lechner, Andreas; Reincke, Martin; Scherberich, Jürgen E; Seissler, Jochen

doi:10.1371/journal.pone.0237364

journal article

Dokumenttyp:: Journal Article; Article
Autor(en):: Then, Cornelia; Thorand, Barbara; Then, Holger L; Meisinger, Christa; Heier, Margit; Peters, Annette; Koenig, Wolfgang; Rathmann, Wolfgang; Bidlingmaier, Martin; Lechner, Andreas; Reincke, Martin; Scherberich, Jürgen E; Seissler, Jochen
Titel:: Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study.
Abstract:: Uromodulin has been associated with arterial hypertension in genome-wide association studies, but data from clinical and preclinical studies are inconsistent. We here analyzed the association of serum uromodulin (sUmod) with arterial hypertension and vasoactive hormones in a population-based study.In 1108 participants of the KORA F4 study aged 62-81 years, sUmod was measured and the association of sUmod with arterial hypertension was assessed using logistic regression models. The associations of sUmod with renin and aldosterone and with the vasoconstrictive prohormone C-terminal pro-endothelin-1 (CT-proET-1) were analyzed in 1079 participants and in 618 participants, respectively, using linear regression models.After multivariable adjustment including sex, age, eGFR, BMI, fasting glucose, current smoking, previous stroke and myocardial infarction, sUmod was inversely associated with arterial hypertension (OR 0.78; 95% CI 0.68-0.91; p = 0.001). SUmod was not significantly associated with renin and aldosterone after adjustment for sex, age and eGFR. However, sUmod was inversely associated with CT-proET-1 (? -0.19 ± 0.04; p < 0.001) after adjustment for sex, age, eGFR, BMI, arterial hypertension, fasting glucose, current smoking, previous stroke and myocardial infarction. The association with CT-proET-1 was stronger in participants with hypertension (? -0.22 ± 0.04) than in normotensive participants (? -0.13 ± 0.06; p for interaction hypertension = 0.003 in the model adjusted for hypertension).SUmod was inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1, suggesting direct or indirect effects of sUmod on blood pressure regulation.
Zeitschriftentitel:: PLoS ONE
Jahr:: 2020
Band / Volume:: 15
Heft / Issue:: 8
Seitenangaben Beitrag:: e0237364
Volltext / DOI:: doi:10.1371/journal.pone.0237364
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/32764816
Print-ISSN:: 1932-6203
TUM Einrichtung:: 273; 602; 656; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2020