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Titel:

Concordance for clonal hematopoiesis is limited in elderly twins.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Fabre, Margarete A; McKerrell, Thomas; Zwiebel, Maximillian; Vijayabaskar, M S; Park, Naomi; Wells, Philippa M; Rad, Roland; Deloukas, Panagiotis; Small, Kerrin; Steves, Claire J; Vassiliou, George S
Abstract:
Although acquisition of leukemia-associated somatic mutations by 1 or more hematopoietic stem cells is inevitable with advancing age, its consequences are highly variable, ranging from clinically silent clonal hematopoiesis (CH) to leukemic progression. To investigate the influence of heritable factors on CH, we performed deep targeted sequencing of blood DNA from 52 monozygotic (MZ) and 27 dizygotic (DZ) twin pairs (aged 70-99 years). Using this highly sensitive approach, we identified CH (vari...     »
Zeitschriftentitel:
Blood
Jahr:
2020
Band / Volume:
135
Heft / Issue:
4
Seitenangaben Beitrag:
269-273
Volltext / DOI:
doi:10.1182/blood.2019001807
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31697828
Print-ISSN:
0006-4971
TUM Einrichtung:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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