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Titel:

Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial-mesenchymal transition and colorectal cancer aggressiveness.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Franke, Fabian C; Slusarenko, Benjamin O; Engleitner, Thomas; Johannes, Widya; Laschinger, Melanie; Rad, Roland; Nitsche, Ulrich; Janssen, Klaus-Peter
Abstract:
Epithelial-mesenchymal transition (EMT) is a cell plasticity process required for metastasis and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor proteins CRK and CRKL in promoting EMT and tumor aggressiveness, as well as resistance against chemotherapy in colorectal and pancreatic carcinoma. Genetic loss of either CRKL or CRK partially counteracted EMT in three independent cancer cell lines. Strikingly, complete loss of the CRK family shifted cells strongly tow...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2020
Band / Volume:
147
Heft / Issue:
6
Seitenangaben Beitrag:
1715-1731
Volltext / DOI:
doi:10.1002/ijc.32955
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32147820
Print-ISSN:
0020-7136
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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