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Title:

Sexual Difference Matters: Females with High Microsatellite Instability Show Increased Survival after Neoadjuvant Chemotherapy in Gastric Cancer.

Document type:
Journal Article
Author(s):
Kohlruss, Meike; Ott, Katja; Grosser, Bianca; Jesinghaus, Moritz; Slotta-Huspenina, Julia; Novotny, Alexander; Hapfelmeier, Alexander; Schmidt, Thomas; Gaida, Matthias M; Weichert, Wilko; Keller, Gisela
Abstract:
We aimed to investigate patients with gastric/gastro-esophageal adenocarcinomas for sex- and age-specific differences regarding overall survival (OS) and response to neoadjuvant chemotherapy (CTx) under consideration of tumor specific molecular subtypes. Overall, 717 patients were analyzed, including 426 patients treated with and 291 treated without neoadjuvant CTx. Microsatellite instability (MSI) and Epstein-Barr virus positivity (EBV+) were determined previously. Females demonstrated a signif...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2021
Journal volume:
13
Journal issue:
5
Fulltext / DOI:
doi:10.3390/cancers13051048
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33801374
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für KI und Informatik in der Medizin (Prof. Rückert); Klinik und Poliklinik für Chirurgie (Prof. Friess); Lehrstuhl für Allgemeinmedizin (Prof. Schneider); Lehrstuhl für Translationale Tumorforschung (DKTK) (Prof. Saur)
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