Benutzer: Gast  Login
Titel:

Constitutive activation of integrin αvβ3 contributes to anoikis resistance of ovarian cancer cells.

Dokumenttyp:
Article; Journal Article
Autor(en):
Dolinschek, Romana; Hingerl, Julia; Benge, Anke; Zafiu, Christian; Schüren, Elisabeth; Ehmoser, Eva-Kathrin; Lössner, Daniela; Reuning, Ute
Abstract:
Epithelial ovarian cancer involves the shedding of single tumor cells or spheroids from the primary tumor into ascites, followed by their survival, and transit to the sites of metastatic colonization within the peritoneal cavity. During their flotation, anchorage-dependent epithelial-type tumor cells gain anoikis resistance, implicating integrins, including αvß3. In this study, we explored anoikis escape, cisplatin resistance, and prosurvival signaling as a function of the αvß3 transmembrane con...     »
Zeitschriftentitel:
Mol Oncol
Jahr:
2021
Band / Volume:
15
Heft / Issue:
2
Seitenangaben Beitrag:
503-522
Volltext / DOI:
doi:10.1002/1878-0261.12845
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33155399
Print-ISSN:
1574-7891
TUM Einrichtung:
Frauenklinik und Poliklinik
 BibTeX