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Title:

Binding of Rap1 and Riam to Talin1 Fine-Tune β2 Integrin Activity During Leukocyte Trafficking.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bromberger, Thomas; Klapproth, Sarah; Rohwedder, Ina; Weber, Jasmin; Pick, Robert; Mittmann, Laura; Min-Weißenhorn, Soo Jin; Reichel, Christoph A; Scheiermann, Christoph; Sperandio, Markus; Moser, Markus
Abstract:
β2 integrins mediate key processes during leukocyte trafficking. Upon leukocyte activation, the structurally bent β2 integrins change their conformation towards an extended, intermediate and eventually high affinity conformation, which mediate slow leukocyte rolling and firm arrest, respectively. Translocation of talin1 to integrin adhesion sites by interactions with the small GTPase Rap1 and the Rap1 effector Riam precede these processes. Using Rap1 binding mutant talin1 and Riam deficient mice...     »
Journal title abbreviation:
Front Immunol
Year:
2021
Journal volume:
12
Fulltext / DOI:
doi:10.3389/fimmu.2021.702345
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34489950
Print-ISSN:
1664-3224
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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