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Title:

Differences in Cell-Intrinsic Inflammatory Programs of Yolk Sac and Bone Marrow Macrophages.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Elhag, Sara; Stremmel, Christopher; Zehrer, Annette; Plocke, Josefine; Hennel, Roman; Keuper, Michaela; Knabe, Clarissa; Winterhalter, Julia; Gölling, Vanessa; Tomas, Lukas; Weinberger, Tobias; Fischer, Maximilian; Liu, Lulu; Wagner, Franziska; Lorenz, Michael; Stark, Konstantin; Häcker, Hans; Schmidt-Supprian, Marc; Völker, Uwe; Jastroch, Martin; Lauber, Kirsten; Straub, Tobias; Walzog, Barbara; Hammer, Elke; Schulz, Christian
Abstract:
BACKGROUND: Tissue-resident macrophages have mixed developmental origins. They derive in variable extent from yolk sac (YS) hematopoiesis during embryonic development. Bone marrow (BM) hematopoietic progenitors give rise to tissue macrophages in postnatal life, and their contribution increases upon organ injury. Since the phenotype and functions of macrophages are modulated by the tissue of residence, the impact of their origin and developmental paths has remained incompletely understood. METHOD...     »
Journal title abbreviation:
Cells
Year:
2021
Journal volume:
10
Journal issue:
12
Fulltext / DOI:
doi:10.3390/cells10123564
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34944072
TUM Institution:
597; Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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