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Title:

In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.

Document type:
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Author(s):
Carlet, Michela; Völse, Kerstin; Vergalli, Jenny; Becker, Martin; Herold, Tobias; Arner, Anja; Senft, Daniela; Jurinovic, Vindi; Liu, Wen-Hsin; Gao, Yuqiao; Dill, Veronika; Fehse, Boris; Baldus, Claudia D; Bastian, Lorenz; Lenk, Lennart; Schewe, Denis M; Bagnoli, Johannes W; Vick, Binje; Schmid, Jan Philipp; Wilhelm, Alexander; Marschalek, Rolf; Jost, Philipp J; Miething, Cornelius; Riecken, Kristoffer; Schmidt-Supprian, Marc; Binder, Vera; Jeremias, Irmela
Abstract:
High-throughput sequencing describes multiple alterations in individual tumors, but their functional relevance is often unclear. Clinic-close, individualized molecular model systems are required for functional validation and to identify therapeutic targets of high significance for each patient. Here, we establish a Cre-ERT2-loxP (causes recombination, estrogen receptor mutant T2, locus of X-over P1) based inducible RNAi- (ribonucleic acid interference) mediated gene silencing system in patient-d...     »
Journal title abbreviation:
Nat Commun
Year:
2021
Journal volume:
12
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-021-25963-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34580292
Print-ISSN:
2041-1723
TUM Institution:
608; 611; Experimentelle Hämatologie (Prof. Schmidt-Supprian); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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