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Titel:

Differences in Cell-Intrinsic Inflammatory Programs of Yolk Sac and Bone Marrow Macrophages.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Elhag, Sara; Stremmel, Christopher; Zehrer, Annette; Plocke, Josefine; Hennel, Roman; Keuper, Michaela; Knabe, Clarissa; Winterhalter, Julia; Gölling, Vanessa; Tomas, Lukas; Weinberger, Tobias; Fischer, Maximilian; Liu, Lulu; Wagner, Franziska; Lorenz, Michael; Stark, Konstantin; Häcker, Hans; Schmidt-Supprian, Marc; Völker, Uwe; Jastroch, Martin; Lauber, Kirsten; Straub, Tobias; Walzog, Barbara; Hammer, Elke; Schulz, Christian
Abstract:
BACKGROUND: Tissue-resident macrophages have mixed developmental origins. They derive in variable extent from yolk sac (YS) hematopoiesis during embryonic development. Bone marrow (BM) hematopoietic progenitors give rise to tissue macrophages in postnatal life, and their contribution increases upon organ injury. Since the phenotype and functions of macrophages are modulated by the tissue of residence, the impact of their origin and developmental paths has remained incompletely understood. METHOD...     »
Zeitschriftentitel:
Cells
Jahr:
2021
Band / Volume:
10
Heft / Issue:
12
Volltext / DOI:
doi:10.3390/cells10123564
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34944072
TUM Einrichtung:
597; Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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