Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Grosch, Melanie; Brunner, Katrin; Ilyaskin, Alexandr V; Schober, Michael; Staudner, Tobias; Schmied, Denise; Stumpp, Tina; Schmidt, Kerstin N; Madej, M Gregor; Pessoa, Thaissa D; Othmen, Helga; Kubitza, Marion; Osten, Larissa; de Vries, Uwe; Mair, Magdalena M; Somlo, Stefan; Moser, Markus; Kunzelmann, Karl; Ziegler, Christine; Haerteis, Silke; Korbmacher, Christoph; Witzgall, Ralph
Abstract:
Mutations in the PKD2 gene cause autosomal-dominant polycystic kidney disease but the physiological role of polycystin-2, the protein product of PKD2, remains elusive. Polycystin-2 belongs to the transient receptor potential (TRP) family of non-selective cation channels. To test the hypothesis that altered ion channel properties of polycystin-2 compromise its putative role in a control circuit controlling lumen formation of renal tubular structures, we generated a mouse model in which we exchang...     »
Zeitschriftentitel:
J Cell Sci
Jahr:
2021
Band / Volume:
134
Heft / Issue:
16
Volltext / DOI:
doi:10.1242/jcs.259013
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34345895
Print-ISSN:
0021-9533
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
 BibTeX