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Title:

Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Erener, Suheda; Ellis, Cara E; Ramzy, Adam; Glavas, Maria M; O'Dwyer, Shannon; Pereira, Sandra; Wang, Tom; Pang, Janice; Bruin, Jennifer E; Riedel, Michael J; Baker, Robert K; Webber, Travis D; Lesina, Marina; Blüher, Matthias; Algül, Hana; Kopp, Janel L; Herzig, Stephan; Kieffer, Timothy J
Abstract:
miRNAs have crucial functions in many biological processes and are candidate biomarkers of disease. Here, we show that miR-216a is a conserved, pancreas-specific miRNA with important roles in pancreatic islet and acinar cells. Deletion of miR-216a in mice leads to a reduction in islet size, β-cell mass, and insulin levels. Single-cell RNA sequencing reveals a subpopulation of β-cells with upregulated acinar cell markers under a high-fat diet. miR-216a is induced by TGF-β signaling, and inhibitio...     »
Journal title abbreviation:
Cell Rep Med
Year:
2021
Journal volume:
2
Journal issue:
11
Fulltext / DOI:
doi:10.1016/j.xcrm.2021.100434
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34841287
TUM Institution:
Lehrstuhl für Tumormetabolismus (Prof. Algül)
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