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Title:

[Pathogenesis of acute pancreatitis].

Document type:
Journal Article; Review
Author(s):
Sendler, Matthias; Algül, Hana
Abstract:
Acute pancreatitis is characterized by the autodigestion of the pancreas by its own digestive enzymes. The pathophysiological onset of the disease occurs in the acinar cells. The normally inactive precursors of secreted proteases are prematurely activated and as a result digest the cells from within. The activation of trypsinogen to trypsin represents the key event as active trypsin activates further digestive enzymes and can therefore initiate the activation of the complete protease cascade. Th...     »
Journal title abbreviation:
Internist (Berl)
Year:
2021
Journal volume:
62
Journal issue:
10
Pages contribution:
1034-1043
Fulltext / DOI:
doi:10.1007/s00108-021-01158-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34529120
Print-ISSN:
0020-9554
TUM Institution:
Lehrstuhl für Tumormetabolismus (Prof. Algül)
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