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Title:

A dual role for hepatocyte-intrinsic canonical NF-?B signaling in virus control.

Document type:
Journal Article; Article
Author(s):
Namineni, Sukumar; O'Connor, Tracy; Faure-Dupuy, Suzanne; Johansen, Pål; Riedl, Tobias; Liu, Kaijing; Xu, Haifeng; Singh, Indrabahadur; Shinde, Prashant; Li, Fanghui; Pandyra, Aleksandra; Sharma, Piyush; Ringelhan, Marc; Muschaweckh, Andreas; Borst, Katharina; Blank, Patrick; Lampl, Sandra; Neuhaus, Katharina; Durantel, David; Farhat, Rayan; Weber, Achim; Lenggenhager, Daniela; Kündig, Thomas M; Staeheli, Peter; Protzer, Ulrike; Wohlleber, Dirk; Holzmann, Bernhard; Binder, Marco; Breuhahn, Kai;...     »
Abstract:
Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resident macrophages. However, hepatocytes, the parenchymal cells of the liver, also possess potent immunological functions in addition to their known metabolic functions. Owing to their abundance in the liver and known immunological functions, we aimed to investigate the direct antiviral mechanisms employed by hepatocytes.Using lymphocytic choriomeningitis virus (LCMV) as a model of liver i...     »
Journal title abbreviation:
J Hepatol
Year:
2020
Journal volume:
72
Journal issue:
5
Pages contribution:
960-975
Fulltext / DOI:
doi:10.1016/j.jhep.2019.12.019
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31954207
Print-ISSN:
0168-8278
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Experimentelle Onkologie und Therapieforschung; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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