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Titel:

Renal proximal tubular NEMO plays a critical role in ischemic acute kidney injury.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Han, Sang Jun; Williams, Ryan M; Kim, Mihwa; Heller, Daniel A; D'Agati, Vivette; Schmidt-Supprian, Marc; Lee, H Thomas
Abstract:
We determined that renal proximal tubular (PT) NF-κB essential modulator (NEMO) plays a direct and critical role in ischemic acute kidney injury (AKI) using mice lacking renal PT NEMO and by targeted renal PT NEMO inhibition with mesoscale nanoparticle-encapsulated NEMO binding peptide (NBP MNP). We subjected renal PT NEMO-deficient mice, WT mice, and C57BL/6 mice to sham surgery or 30 minutes of renal ischemia and reperfusion (IR). C57BL/6 mice received NBP MNP or empty MNP before renal IR inju...     »
Zeitschriftentitel:
JCI Insight
Jahr:
2020
Band / Volume:
5
Heft / Issue:
19
Volltext / DOI:
doi:10.1172/jci.insight.139246
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32941183
Print-ISSN:
2379-3708
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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