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Document type:
Journal Article; Article
Author(s):
Margraf, Andreas; Germena, Giulia; Drexler, Hannes C A; Rossaint, Jan; Ludwig, Nadine; Prystaj, Barbara; Mersmann, Sina; Thomas, Katharina; Block, Helena; Gottschlich, Wiebke; Liu, Chang; Krenn, Peter W; Haller, Hermann; Heitplatz, Barbara; Meyer Zu Brickwedde, Marika; Moser, Markus; Vestweber, Dietmar; Zarbock, Alexander
Title:
The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1.
Abstract:
Neutrophil adhesion and extravasation into tissue at sites of injury or infection depend on binding of the integrin lymphocyte function-associated antigen 1 (LFA-1) to ICAM-1 expressed on activated endothelial cells. The activation-dependent conformational change of LFA-1 to the high-affinity conformation (H+) requires kindlin-3 binding to the β2-integrin cytoplasmic domain. Here we show that genetic deletion of the known kindlin interactor integrin-linked kinase (ILK) impaired neutrophil adhesi...     »
Journal title abbreviation:
Blood
Year:
2020
Journal volume:
136
Journal issue:
19
Pages contribution:
2200-2205
Fulltext / DOI:
doi:10.1182/blood.2020004948
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32730588
Print-ISSN:
0006-4971
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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