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Titel:

Characterization and implications of the initial estimated glomerular filtration rate 'dip' upon sodium-glucose cotransporter-2 inhibition with empagliflozin in the EMPA-REG OUTCOME trial.

Dokumenttyp:
Article; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Autor(en):
Kraus, Bettina J; Weir, Matthew R; Bakris, George L; Mattheus, Michaela; Cherney, David Z I; Sattar, Naveed; Heerspink, Hiddo J L; Ritter, Ivana; von Eynatten, Maximilian; Zinman, Bernard; Inzucchi, Silvio E; Wanner, Christoph; Koitka-Weber, Audrey
Abstract:
Treatment with sodium-glucose co-transporter-2 inhibitors induces an initial 3-5 ml/min/1.73 m2 decline in estimated glomerular filtration rate (eGFR). Although considered to be of hemodynamic origin and largely reversible, this 'eGFR dip' may cause concern in clinical practice, which highlights the need to better understand its incidence and clinical implications. In this post hoc analysis of the EMPA-REG OUTCOME trial, 6,668 participants randomized to empagliflozin 10 mg, 25 mg or placebo with...     »
Zeitschriftentitel:
Kidney Int
Jahr:
2021
Band / Volume:
99
Heft / Issue:
3
Seitenangaben Beitrag:
750-762
Volltext / DOI:
doi:10.1016/j.kint.2020.10.031
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33181154
Print-ISSN:
0085-2538
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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