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Titel:

Assessment of α-amanitin toxicity and effects of silibinin and penicillin in different in vitro models.

Dokumenttyp:
Article; Comparative Study; Journal Article
Autor(en):
Popp, Tanja; Balszuweit, Frank; Schmidt, Annette; Eyer, Florian; Thiermann, Horst; Steinritz, Dirk
Abstract:
Silibinin (Sil) is used as hepatoprotective drug and is approved for therapeutic use in amanitin poisoning. In our study we compared Sil-bis-succinate (SilBS), a water-soluble drug approved for i.v.-administration, with Sil solved in ethanol (SilEtOH), which is normally used in research. We challenged monocultures or 3D-microtissues consisting of HepG2 cells or primary hepatocytes with α-amanitin and treated with SILBS, SILEtOH, penicillin and combinations thereof. Cell viability and the integri...     »
Zeitschriftentitel:
Toxicol In Vitro
Jahr:
2020
Band / Volume:
67
Volltext / DOI:
doi:10.1016/j.tiv.2020.104921
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32599260
Print-ISSN:
0887-2333
TUM Einrichtung:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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