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Titel:

Oscillating calcium signals in smooth muscle cells underlie the persistent basal tone of internal anal sphincter.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Lu, Ping; Chen, Jun; Zhang, Chenghai; Saur, Dieter; Baer, Christina E; Lifshitz, Lawrence M; Fogarty, Kevin E; ZhuGe, Ronghua
Abstract:
A persistent basal tone in the internal anal sphincter (IAS) is essential for keeping the anal canal closed and fecal continence; its inhibition via the rectoanal inhibitory reflex (RAIR) is required for successful defecation. However, cellular signals underlying the IAS basal tone remain enigmatic. Here we report the origin and molecular mechanisms of calcium signals that control the IAS basal tone, using a combination approach including a novel IAS slice preparation that retains cell arrangem...     »
Zeitschriftentitel:
J Cell Physiol
Jahr:
2021
Band / Volume:
236
Heft / Issue:
8
Seitenangaben Beitrag:
5937-5952
Volltext / DOI:
doi:10.1002/jcp.30279
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33452672
Print-ISSN:
0021-9541
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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