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Titel:

Context-dependent modulation of aggressiveness of pediatric tumors by individual oncogenic RAS isoforms.

Dokumenttyp:
Journal Article
Autor(en):
Bauer, Julia; Cuvelier, Nicole; Ragab, Nada; Simon-Keller, Katja; Nitzki, Frauke; Geyer, Natalie; Botermann, Dominik S; Elmer, Dominik P; Rosenberger, Albert; Rando, Thomas A; Biressi, Stefano; Fagin, James A; Saur, Dieter; Dullin, Christian; Schildhaus, Hans-Ulrich; Schulz-Schaeffer, Walter; Aberger, Fritz; Uhmann, Anja; Hahn, Heidi
Abstract:
A prototypic pediatric cancer that frequently shows activation of RAS signaling is embryonal rhabdomyosarcoma (ERMS). ERMS also show aberrant Hedgehog (HH)/GLI signaling activity and can be driven by germline mutations in this pathway. We show, that in ERMS cell lines derived from sporadic tumors i.e. from tumors not caused by an inherited genetic variant, HH/GLI signaling plays a subordinate role, because oncogenic mutations in HRAS, KRAS, or NRAS (collectively named oncRAS) inhibit the main HH...     »
Zeitschriftentitel:
Oncogene
Jahr:
2021
Band / Volume:
40
Heft / Issue:
31
Seitenangaben Beitrag:
4955-4966
Volltext / DOI:
doi:10.1038/s41388-021-01904-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34172934
Print-ISSN:
0950-9232
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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