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Title:

Oscillating calcium signals in smooth muscle cells underlie the persistent basal tone of internal anal sphincter.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Lu, Ping; Chen, Jun; Zhang, Chenghai; Saur, Dieter; Baer, Christina E; Lifshitz, Lawrence M; Fogarty, Kevin E; ZhuGe, Ronghua
Abstract:
A persistent basal tone in the internal anal sphincter (IAS) is essential for keeping the anal canal closed and fecal continence; its inhibition via the rectoanal inhibitory reflex (RAIR) is required for successful defecation. However, cellular signals underlying the IAS basal tone remain enigmatic. Here we report the origin and molecular mechanisms of calcium signals that control the IAS basal tone, using a combination approach including a novel IAS slice preparation that retains cell arrangem...     »
Journal title abbreviation:
J Cell Physiol
Year:
2021
Journal volume:
236
Journal issue:
8
Pages contribution:
5937-5952
Fulltext / DOI:
doi:10.1002/jcp.30279
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33452672
Print-ISSN:
0021-9541
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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