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Title:

The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations.

Document type:
Journal Article
Author(s):
Willvonseder, Barbara; Stögbauer, Fabian; Steiger, Katja; Jesinghaus, Moritz; Kuhn, Peer-Hendrik; Brambs, Christine; Engel, Jutta; Bronger, Holger; Schmidt, Georg Philipp; Haller, Bernhard; Weichert, Wilko; Keller, Gisela; Noske, Aurelia; Pfarr, Nicole; Boxberg, Melanie
Abstract:
OBJECTIVE: POLE-mutant, microsatellite-instable (MSI), p53-mutant and non-specific molecular profile (NSMP) are TCGA-defined molecular subgroups of endometrial cancer (EC). Hypothesizing that morphology and tumor immunology might differ depending on molecular background concerning composition and prognostic impact, we aimed to comprehensively interconnect morphologic, immunologic and molecular data. METHODS: TCGA-defined molecular groups were determined by immunohistochemistry and sequencing in...     »
Journal title abbreviation:
Cancer Immunol Immunother
Year:
2021
Journal volume:
70
Journal issue:
6
Pages contribution:
1679-1689
Fulltext / DOI:
doi:10.1007/s00262-020-02813-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33340331
Print-ISSN:
0340-7004
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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