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Title:

Context-dependent modulation of aggressiveness of pediatric tumors by individual oncogenic RAS isoforms.

Document type:
Journal Article
Author(s):
Bauer, Julia; Cuvelier, Nicole; Ragab, Nada; Simon-Keller, Katja; Nitzki, Frauke; Geyer, Natalie; Botermann, Dominik S; Elmer, Dominik P; Rosenberger, Albert; Rando, Thomas A; Biressi, Stefano; Fagin, James A; Saur, Dieter; Dullin, Christian; Schildhaus, Hans-Ulrich; Schulz-Schaeffer, Walter; Aberger, Fritz; Uhmann, Anja; Hahn, Heidi
Abstract:
A prototypic pediatric cancer that frequently shows activation of RAS signaling is embryonal rhabdomyosarcoma (ERMS). ERMS also show aberrant Hedgehog (HH)/GLI signaling activity and can be driven by germline mutations in this pathway. We show, that in ERMS cell lines derived from sporadic tumors i.e. from tumors not caused by an inherited genetic variant, HH/GLI signaling plays a subordinate role, because oncogenic mutations in HRAS, KRAS, or NRAS (collectively named oncRAS) inhibit the main HH...     »
Journal title abbreviation:
Oncogene
Year:
2021
Journal volume:
40
Journal issue:
31
Pages contribution:
4955-4966
Fulltext / DOI:
doi:10.1038/s41388-021-01904-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34172934
Print-ISSN:
0950-9232
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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