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Title:

Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Thibault, Benoit; Ramos-Delgado, Fernanda; Pons-Tostivint, Elvire; Therville, Nicole; Cintas, Celia; Arcucci, Silvia; Cassant-Sourdy, Stephanie; Reyes-Castellanos, Gabriela; Tosolini, Marie; Villard, Amelie V; Cayron, Coralie; Baer, Romain; Bertrand-Michel, Justine; Pagan, Delphine; Ferreira Da Mota, Dina; Yan, Hongkai; Falcomatà, Chiara; Muscari, Fabrice; Bournet, Barbara; Delord, Jean-Pierre; Aksoy, Ezra; Carrier, Alice; Cordelier, Pierre; Saur, Dieter; Basset, Celine; Guillermet-Guibert, Juli...     »
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) patients frequently suffer from undetected micro-metastatic disease. This clinical situation would greatly benefit from additional investigation. Therefore, we set out to identify key signalling events that drive metastatic evolution from the pancreas. We searched for a gene signature that discriminate localised PDAC from confirmed metastatic PDAC and devised a preclinical protocol using circulating cell-free DNA (cfDNA) as an early biomarker of micro-meta...     »
Journal title abbreviation:
EMBO Mol Med
Year:
2021
Journal volume:
13
Journal issue:
7
Fulltext / DOI:
doi:10.15252/emmm.202013502
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34033220
Print-ISSN:
1757-4676
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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