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Title:

The Missing Link: Cre Pigs for Cancer Research.

Document type:
Journal Article
Author(s):
Kalla, Daniela; Flisikowski, Krzysztof; Yang, Kaiyuan; Sangüesa, Laura Beltran; Kurome, Mayuko; Kessler, Barbara; Zakhartchenko, Valeri; Wolf, Eckhard; Lickert, Heiko; Saur, Dieter; Schnieke, Angelika; Flisikowska, Tatiana
Abstract:
The Cre/loxP system is a powerful tool for the generation of animal models with precise spatial and temporal gene expression. It has proven indispensable in the generation of cancer models with tissue specific expression of oncogenes or the inactivation of tumor suppressor genes. Consequently, Cre-transgenic mice have become an essential prerequisite in basic cancer research. While it is unlikely that pigs will ever replace mice in basic research they are already providing powerful complementary...     »
Journal title abbreviation:
Front Oncol
Year:
2021
Journal volume:
11
Fulltext / DOI:
doi:10.3389/fonc.2021.755746
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34692545
Print-ISSN:
2234-943X
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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