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Title:

Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Maruno, Takahisa; Fukuda, Akihisa; Goto, Norihiro; Tsuda, Motoyuki; Ikuta, Kozo; Hiramatsu, Yukiko; Ogawa, Satoshi; Nakanishi, Yuki; Yamaga, Yuichi; Yoshioka, Takuto; Takaori, Kyoichi; Uemoto, Shinji; Saur, Dieter; Chiba, Tsutomu; Seno, Hiroshi
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of 'cancer stem cells (CSCs)' in PDAC and molecular markers for them, stem cell dynamics in vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk1), known as a CSC marker of PDAC. Using genetic lineage tracing with a dual-recombinase system and live imaging, we showed that Dclk1+ tumor cells continuously provided progeny cells within pancreati...     »
Journal title abbreviation:
Elife
Year:
2021
Journal volume:
10
Fulltext / DOI:
doi:10.7554/eLife.55117
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33393460
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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