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Title:

Dual recombinase action in the normal and neoplastic mammary gland epithelium.

Document type:
Journal Article; Research Support, N.I.H., Extramural
Author(s):
Rädler, Patrick D; Vistisen, Kerry; Triplett, Aleata A; Dennaoui, Rayane; Li, Yong; Shrestha, Hridaya; Ferraiuolo, Rosa-Maria; Thangasamy, Amalraj; Saur, Dieter; Wagner, Kay-Uwe
Abstract:
We developed a transgenic mouse line that expresses the codon-optimized Flp recombinase under the control of the MMTV promoter in luminal epithelial cells of the mammary gland. In this report, we demonstrate the versatile applicability of the new MMTV-Flp strain to manipulate genes in a temporally and spatially controlled manner in the normal mammary gland, in luminal-type mammary tumors that overexpress ERBB2, and in a new KRAS-associated mammary cancer model. Although the MMTV-Flp is expressed...     »
Journal title abbreviation:
Sci Rep
Year:
2021
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-021-00231-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34675248
Print-ISSN:
2045-2322
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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