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Title:

IDO1+ Paneth cells promote immune escape of colorectal cancer.

Document type:
Journal Article
Author(s):
Pflügler, Sandra; Svinka, Jasmin; Scharf, Irene; Crncec, Ilija; Filipits, Martin; Charoentong, Pornpimol; Tschurtschenthaler, Markus; Kenner, Lukas; Awad, Monira; Stift, Judith; Schernthanner, Marina; Bischl, Romana; Herndler-Brandstetter, Dietmar; Glitzner, Elisabeth; Moll, Herwig P; Casanova, Emilio; Timelthaler, Gerald; Sibilia, Maria; Gnant, Michael; Lax, Sigurd; Thaler, Josef; Müller, Mathias; Strobl, Birgit; Mohr, Thomas; Kaser, Arthur; Trajanoski, Zlatko; Heller, Gerwin; Eferl, Robert
Abstract:
Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune attack is an important strategy to revert immunosuppression. However, the underlying mechanisms of immune escape are still poorly understood. Here we discover Indoleamine-2,3-dioxygenase-1 (IDO1)+ Paneth cells in the stem cell niche of intestinal crypts and tumors, which promoted imm...     »
Journal title abbreviation:
Commun Biol
Year:
2020
Journal volume:
3
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s42003-020-0989-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32444775
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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